Recent work of researchers from the Universities of Exeter, Leeds and Cambridge has been featured in a number of press reports.
In particular, the Yorkshire Evening Post refer to the recently published paper in Cell Reports in their statement that “A pioneering new technique could boost the understanding of the causes of heart disease, a study suggests.”
Professor Christian Soeller, based at the Living Systems Institute at the University of Exeter expands upon the pioneering nature of this research, stating: “Slightly more than a decade ago nobody thought that we would ever see individual molecules with light, the resolution just seemed insufficient to resolve such fine detail. Since then an astonishing array of new tricks has been devised. In our latest advance, the use of synthetic DNA has been critical – the deep understanding of the chemistry of DNA we have today makes it an enormously versatile tool.”
Dr Isuru Jayasinghe, at the University of Leeds, has provided context to this research in regard to heart failure, having said that: “This new super-resolution microscopy tool gives us the perfect window to visually examine the individual protein changes within heart cells’ molecular machinery which lead to heart failure. At present, none of the treatments or therapies provided to heart failure patients specifically target the signalling stations – nanodomains – within the cell, which the evidence overwhelmingly suggests are a major cause of heart failure. We believe that by visualising these signalling structures at this level of detail using super-resolution microscopy we can help guide investigations into how we can target or repair these molecular machines and thus, in the long term, help patients to overcome heart disease.”
Here at the University of Leeds, Dr Isuru Jayasinghe’s group is utilising multiple super-resolution microscopy techniques to reveal further the fine structural properties of the heart within health and disease.
See the University of Leeds Science News page http://www.leeds.ac.uk/news/article/4167/pioneering_technique_could_boost_understanding_of_heart_disease
European Pharmaceutical Review: https://www.europeanpharmaceuticalreview.com/news/71582/powerful-technique-study-nanodomains/